Restylane® vs. Perlane® Filler

Juvéderm® like Perlane is a filler that relies on hyaluronic acid rather than collagen to plump up the skin. Hyaluronic acid is a substance naturally found in the human body. Since the hyaluronic acid in Juvéderm® is created by biosynthesis in a laboratory, patients are not required to take an allergy test before receiving treatment.


The hyaluronic acid in Perlane® supplements the body's natural supply, which becomes depleted with age. Perlane® is biodegradable so its effects are not permanent. The results of a Perlane® filler treatment tend to last six months to a year. This is much longer than the typical results of collagen injections, which may only last three to six months.

Perlane® is made from non-animal stabilized hyaluronic acid (NASHA) gel. This means that Perlane® contains no animal products. Since hyaluronic acid is a natural substance found in the skin and other tissue, there is no need for a skin test when using Perlane® filler.

Perlane® is primarily the same product as Restylane®, but Perlane® filler contains a larger concentration of hyaluronic acid. Because of this higher concentration of hyaluronic acid, Perlane® is usually used for larger folds, while Restylane® is better suited for smaller wrinkles or to maintain the results of a previous Perlane® injection.

Because of the differing levels of hyaluronic acid, Restylane® is less expensive than Perlane® filler, and Perlane® lasts longer.

The benefits of Juvéderm® filler injections are easy to see: immediate improvement in the appearance of wrinkles and creases, and fuller lips for those who wish to augment this aspect of their face. Risks are few, as the materials contained in Juvéderm® filler are naturally produced in the human body and are therefore not allergy-inducing. There is a side effect of swelling at the injection site, but this is normal and subsides rapidly after treatment

Some areas that are recommended for Perlane are:

• Wrinkle correction

• Diminishing worry lines, smile lines, crow's feet, marionette lines at corners of the mouth, and smoker's lines

• Lip enhancement

• Reducing the severity of nasolabial folds

• Chin augmentation

• Filling cheek depressions

• Redefining lip border

• Softening acne scars

Other, less common, uses for Perlane® filler include:

• Filling hollows under the eyes

• Creating a temporary eyebrow lift

• Correcting facial depressions caused by fat loss

• Softening the appearance of jowls